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In the world of magic, there exist deadly irreversible techniques commonly known as spellblades. These sparse and elusive spells, along with their casters, are shrouded in mystery and only their absolute lethality is known to the masses. Every year, the spring blossom signifies a new intake of students to the prestigious magic school Kimberly. With reactions of awe and bewilderment, a ceremonious parade complete with magical beasts welcomes the newcomers to the institution. Among them is the mysterious Oliver Horn, whose indifference changes to fascination as he notices a peculiar figure—a girl wearing strange attire equipped with a Japanese sword. From the entrance ceremony onward, Oliver realizes that not all is as it seems at Kimberly, as the emergence of labyrinths, monsters, and other threats endanger the new student body. Nanatsu no Maken ga Shihai suru explores the intertwined fates of two warriors as they uncover the dark truths that lurk within the walls of the academy.

One day, Nobita finds a stray dog drowning in a river while playing by the river side. Feeling sorry for the dog, he decides to take it home by hiding it in a "kennel on the wall" and names it Ichi (originated from "One", which sounds similar to "wan", the sound a dog makes according to the Japanese language), and secretly feeds it and plays with Ichi with his Kendama to find. Soon after, he also adopts a stray cat named Zubu (or wet in Japanese, due to the discovery of it in a rainstorm)... and many other stray cats and dogs. With so many stray cats and dogs, Nobita, along with his friends, decide to send them back in time, 300 million years ago, where there was no other living beings around. After using the Ray of Evolution to allow them to operate a food-making machine, they depart, with a promise to return to the present. However, when they try to visit them the next day (from their point of view), they encountered a time-space anomaly, sending them crash landing 1,000 years before their original time-destination— to their surprise, They found out the dogs and cats have evolved enough to form a civilized society that rivaled those of Future Society. As the time machine is broken, they try to find help to repair it so they can continue their chrono-journey, only to learn of a bigger issue — a cluster of asteroids are going to Collide with Earth. Will Nobita finally reunite with Ichi, as he promised? More over, what's with Hachi, a dog who resembles Ichi greatly? The 300 million years of time and space adventure begins.

After bragging about receiving a space trip ticket from his father, Suneo concedes they would have to wait quite a while until they can actually go. So, Nobita and co. turns to Doraemon for it, but they were given a space simulation game to play together instead. Unfortunately an accident with another gadget occurred, leaving Suneo and Giant trapped inside the game, only to be picked up by someone from outer space. Nobita, Shizuka and Doraemon then pursued the UFO that has the game inside it which took them all to a real space adventure.